Version 5.4
Homo sapiens Gene: PPT2
Summary
InnateDB Gene IDBG-281622.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPT2
Gene Name palmitoyl-protein thioesterase 2
Synonyms C6orf8; G14; PPT-2;
Species Homo sapiens
Ensembl Gene ENSG00000221988
Encoded Proteins
IDBP-80328
palmitoyl-protein thioesterase 2
IDBP-80330
palmitoyl-protein thioesterase 2
IDBP-80332
palmitoyl-protein thioesterase 2
IDBP-80334
palmitoyl-protein thioesterase 2
IDBP-239350
palmitoyl-protein thioesterase 2
IDBP-374060
palmitoyl-protein thioesterase 2
IDBP-374104
palmitoyl-protein thioesterase 2
IDBP-374109
palmitoyl-protein thioesterase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32153441-32163680
Strand Forward strand
Band p21.32
Transcripts
ENST00000375143 ENSP00000364285
ENST00000361568 ENSP00000354608
ENST00000324816 ENSP00000320528
ENST00000375137 ENSP00000364279
ENST00000395523 ENSP00000378894
ENST00000414204 ENSP00000398847
ENST00000424499 ENSP00000409877
ENST00000436118 ENSP00000395456
ENST00000478521
ENST00000493548
ENST00000465047
ENST00000495908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 27 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016790 thiolester hydrolase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0008152 metabolic process
Cellular Component
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000015474
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000004436
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa00062
Fatty acid elongation pathway
hsa04142
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.332138 Hs.737984
RefSeq NM_001204103 NM_005155 NM_138717
HUGO
OMIM
CCDS CCDS4740 CCDS4742
HPRD 04486
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca