Version 5.4
Homo sapiens Protein: PPT2
Summary
InnateDB Protein IDBP-80334.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPT2
Protein Name palmitoyl-protein thioesterase 2
Synonyms C6orf8; G14; PPT-2;
Species Homo sapiens
Ensembl Protein ENSP00000364279
InnateDB Gene IDBG-281622 (PPT2)
Protein Structure
UniProt Annotation
Function Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. {ECO:0000269PubMed:10417332, ECO:0000269PubMed:12855696, ECO:0000269PubMed:9341199}.
Subcellular Localization Lysosome {ECO:0000269PubMed:9341199}.
Disease Associations
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269PubMed:9341199}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 27 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016790 thiolester hydrolase activity
Biological Process
GO:0006464 cellular protein modification process
Cellular Component
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002472 Palmitoyl protein thioesterase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF02089
PRINTS PR00414
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UMR5
PhosphoSite PhosphoSite-
TrEMBL G8JLL2
UniProt Splice Variant
Entrez Gene 9374
UniGene Hs.737984
RefSeq
HUGO HGNC:9326
OMIM 603298
CCDS CCDS4742
HPRD 04486
IMGT
EMBL AF020543 AF020544 AK292729 AL110128 AL662828 AL662884 AL845464 BC001355 BX284686 BX927239 CH471081 CR533546 CR753803 CR812478 CR933878 U89336 Y17958
GenPept AAB47495 AAB80730 AAB80731 AAH01355 BAF85418 CAB46981 CAB53659 CAG38577 CAI17424 CAI17426 CAI18342 CAI18344 CAI41763 CAI41797 CAI41798 CAI41799 CAM24823 CAM24825 CAM25714 CAM26213 CAM26215 CAM26216 CAM26218 CAQ06588 CAQ06590 CAQ09561 CAQ09617 CAQ09619 CAQ10692 CAQ10694 EAX03591 EAX03597

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca