Homo sapiens Gene: MAPK10
Summary
InnateDB Gene IDBG-28343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK10
Gene Name mitogen-activated protein kinase 10
Synonyms JNK3; JNK3A; p493F12; p54bSAPK; PRKM10; SAPK1b;
Species Homo sapiens
Ensembl Gene ENSG00000109339
Encoded Proteins
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
mitogen-activated protein kinase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:86015123-86594131
Strand Reverse strand
Band q21.3
Transcripts
ENST00000361569 ENSP00000355297
ENST00000310816 ENSP00000309857
ENST00000359221 ENSP00000352157
ENST00000395169 ENSP00000378598
ENST00000395166 ENSP00000378595
ENST00000395161 ENSP00000378590
ENST00000395160 ENSP00000378589
ENST00000395157 ENSP00000378586
ENST00000430389
ENST00000449047 ENSP00000414469
ENST00000508262
ENST00000515400 ENSP00000424154
ENST00000489368
ENST00000472236
ENST00000468020
ENST00000479377
ENST00000486985
ENST00000513839
ENST00000512017 ENSP00000424755
ENST00000475679
ENST00000512564 ENSP00000422985
ENST00000511167 ENSP00000422277
ENST00000511328 ENSP00000421762
ENST00000509464 ENSP00000424128
ENST00000506773 ENSP00000421359
ENST00000512689 ENSP00000425654
ENST00000502302 ENSP00000423918
ENST00000503911 ENSP00000421409
ENST00000513186 ENSP00000420987
ENST00000505356
ENST00000504397
ENST00000506385
ENST00000514856
ENST00000512046
ENST00000515650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0008152 metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSLP pathway
REACTOME
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activation of the AP-1 family of transcription factors pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
MAP kinase activation in TLR cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Cellular Senescence pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
INOH
TNFR1 signaling pathway pathway
Fas signaling pathway pathway
TGF-beta signaling pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL Q499Y8
UniProt Splice Variant
Entrez Gene 5602
UniGene Hs.125503 Hs.598548 Hs.666725 Hs.739136
RefSeq NM_002753 NM_138980 NM_138981 NM_138982 XM_005263129 XM_005263130 XM_005263131 XM_005263135 XM_006714267 XM_006714269
HUGO HGNC:6872
OMIM 602897
CCDS CCDS34026 CCDS3612 CCDS3613 CCDS43247
HPRD 04207
IMGT
EMBL AC096953 AC104059 AC104827 AC108054 AC110076 BC051731
GenPept AAH51731
RNA Seq Atlas 5602