Homo sapiens Gene: TNFSF11
InnateDB Gene IDBG-28393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF11
Gene Name tumor necrosis factor (ligand) superfamily, member 11
Synonyms CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TRANCE;
Species Homo sapiens
Ensembl Gene ENSG00000120659
Encoded Proteins
tumor necrosis factor (ligand) superfamily, member 11
tumor necrosis factor (ligand) superfamily, member 11
tumor necrosis factor (ligand) superfamily, member 11
tumor necrosis factor (ligand) superfamily, member 11
tumor necrosis factor (ligand) superfamily, member 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
TLR2 and TNFSF11 signalling pathways are modulated by Porphromonas gingivalis to alter the differentiation states of osteoclasts resulting in bacteria-mediated bone loss. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
[Mus musculus] Tlr2 and Tnfsf11 signalling pathways are modulated by Porphromonas gingivalis to alter the differentiation states of osteoclasts resulting in bacteria-mediated bone loss.
Entrez Gene
Summary This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:42562736-42608013
Strand Forward strand
Band q14.11
ENST00000358545 ENSP00000351347
ENST00000239849 ENSP00000239849
ENST00000398795 ENSP00000381775
ENST00000405262 ENSP00000384042
ENST00000544862 ENSP00000444913
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0001503 ossification
GO:0002158 osteoclast proliferation
GO:0002548 monocyte chemotaxis
GO:0006955 immune response
GO:0007257 activation of JUN kinase activity
GO:0009887 organ morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030316 osteoclast differentiation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033598 mammary gland epithelial cell proliferation
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0042327 positive regulation of phosphorylation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045453 bone resorption
GO:0045670 regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0050870 positive regulation of T cell activation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051466 positive regulation of corticotropin-releasing hormone secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0055074 calcium ion homeostasis
GO:0060749 mammary gland alveolus development
GO:0070371 ERK1 and ERK2 cascade
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 TNFSF11-mediated signaling pathway
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533 positive regulation of intracellular signal transduction
GO:2001206 positive regulation of osteoclast development
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
RANKL pathway
Cytokine-cytokine receptor interaction pathway
Osteoclast differentiation pathway
Bone remodeling [Biocarta view]
IL6-mediated signaling events
SwissProt O14788
UniProt Splice Variant
Entrez Gene 8600
UniGene Hs.333791
RefSeq NM_003701 NM_033012
OMIM 602642
HPRD 04031
EMBL AB037599 AB061227 AB064268 AB064269 AB064270 AF013171 AF019047 AF053712 BC074823 BC074890 CH471075
GenPept AAB86811 AAC39731 AAC51762 AAH74823 AAH74890 BAA90488 BAB71768 BAB79693 BAB79694 BAB79695 EAX08680
RNA Seq Atlas 8600