Homo sapiens Gene: ADORA2A
Summary
InnateDB Gene IDBG-2843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA2A
Gene Name adenosine A2a receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128271
Encoded Proteins
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
adenosine A2a receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24417879-24442360
Strand Forward strand
Band q11.23
Transcripts
ENST00000337539 ENSP00000336630
ENST00000424232 ENSP00000404497
ENST00000444262 ENSP00000414802
ENST00000436735 ENSP00000397071
ENST00000439591 ENSP00000400190
ENST00000467385
ENST00000486351
ENST00000486108 ENSP00000473799
ENST00000464977 ENSP00000474895
ENST00000496258 ENSP00000474097
ENST00000496497
ENST00000472248 ENSP00000475000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007267 cell-cell signaling
GO:0007417 central nervous system development
GO:0007596 blood coagulation
GO:0007600 sensory perception
GO:0008015 blood circulation
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signalling by NGF pathway
Class A/1 (Rhodopsin-like receptors) pathway
NGF-independant TRKA activation pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adenosine P1 receptors pathway
NGF signalling via TRKA from the plasma membrane pathway
GPCR ligand binding pathway
Activation of TRKA receptors pathway
Nucleotide-like (purinergic) receptors pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Vascular smooth muscle contraction pathway
Parkinson's disease pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
PID BIOCARTA
PID NCI
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.197029 Hs.691096
RefSeq NM_000675 NM_001278499
HUGO
OMIM
CCDS CCDS13826
HPRD 00043
IMGT
EMBL
GenPept
RNA Seq Atlas