Version 5.4
Homo sapiens Gene: SLC5A2
Summary
InnateDB Gene IDBG-28583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A2
Gene Name solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms SGLT2
Species Homo sapiens
Ensembl Gene ENSG00000140675
Encoded Proteins
IDBP-28585
solute carrier family 5 (sodium/glucose cotransporter), member 2
IDBP-376187
solute carrier family 5 (sodium/glucose cotransporter), member 2
IDBP-753185
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31483002-31490860
Strand Forward strand
Band p11.2
Transcripts
ENST00000330498 ENSP00000327943
ENST00000419665 ENSP00000410601
ENST00000565446
ENST00000562006
ENST00000567051
ENST00000568188
ENST00000568891
ENST00000564197
ENST00000569576 ENSP00000455143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005362 low-affinity glucose:sodium symporter activity
GO:0005515 protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0015758 glucose transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030781
View Gene Order
ENSBTAG00000010096
Not yet available
Pathways
NETPATH
REACTOME
REACT_19188
Inositol transporters pathway
REACT_19165
Na+-dependent glucose transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_9441
Hexose transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267716
Orphan transporters pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.663690 Hs.709195
RefSeq NM_003041 XM_006721073
HUGO
OMIM
CCDS CCDS10714
HPRD 08919
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca