Version 5.4
Homo sapiens Protein: SLC5A2
Summary
InnateDB Protein IDBP-28585.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A2
Protein Name solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms SGLT2;
Species Homo sapiens
Ensembl Protein ENSP00000327943
InnateDB Gene IDBG-28583 (SLC5A2)
Protein Structure
UniProt Annotation
Function Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations Renal glucosuria (GLYS1) [MIM:233100]: Autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. {ECO:0000269PubMed:14614622}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005362 low-affinity glucose:sodium symporter activity
GO:0005515 protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0015758 glucose transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001734 Sodium/solute symporter
IPR019900 Sodium/solute symporter, subgroup
PFAM PF00474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31639
PhosphoSite PhosphoSite-P31639
TrEMBL H3BP44
UniProt Splice Variant
Entrez Gene 6524
UniGene Hs.709195
RefSeq NP_003032
HUGO HGNC:11037
OMIM 182381
CCDS CCDS10714
HPRD 08919
IMGT
EMBL AC026471 M95549
GenPept AAA36608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca