Homo sapiens Gene: CCKBR
Summary
InnateDB Gene IDBG-28586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCKBR
Gene Name cholecystokinin B receptor
Synonyms CCK-B; CCK2R; GASR;
Species Homo sapiens
Ensembl Gene ENSG00000110148
Encoded Proteins
cholecystokinin B receptor
cholecystokinin B receptor
cholecystokinin B receptor
cholecystokinin B receptor
cholecystokinin B receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6259736-6272127
Strand Forward strand
Band p15.4
Transcripts
ENST00000334619 ENSP00000335544
ENST00000532715 ENSP00000432079
ENST00000525014 ENSP00000437001
ENST00000531712 ENSP00000435675
ENST00000525462 ENSP00000435534
ENST00000532396
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004930 G-protein coupled receptor activity
GO:0004951 cholecystokinin receptor activity
GO:0005515 protein binding
GO:0015054 gastrin receptor activity
GO:0031741 type B gastrin/cholecystokinin receptor binding
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
Biological Process
GO:0001696 gastric acid secretion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007586 digestion
GO:0007600 sensory perception
GO:0007631 feeding behavior
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0038188 cholecystokinin signaling pathway
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0048565 digestive tract development
GO:0048732 gland development
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Gastric acid secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.203
RefSeq NM_176875 XM_005253210
HUGO
OMIM
CCDS CCDS7761
HPRD 00323
IMGT
EMBL
GenPept
RNA Seq Atlas