Homo sapiens Gene: NPTX2
Summary
InnateDB Gene IDBG-28612.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPTX2
Gene Name neuronal pentraxin II
Synonyms NARP; NP-II; NP2;
Species Homo sapiens
Ensembl Gene ENSG00000106236
Encoded Proteins
neuronal pentraxin II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:98617297-98629868
Strand Forward strand
Band q22.1
Transcripts
ENST00000265634 ENSP00000265634
ENST00000466102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0046872 metal ion binding
Biological Process
GO:0007268 synaptic transmission
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.3281 Hs.603562
RefSeq NM_002523
HUGO
OMIM
CCDS CCDS5657
HPRD 02853
IMGT
EMBL
GenPept
RNA Seq Atlas