Homo sapiens Gene: TSC22D1
Summary
InnateDB Gene IDBG-28907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSC22D1
Gene Name TSC22 domain family, member 1
Synonyms Ptg-2; TGFB1I4; TSC22;
Species Homo sapiens
Ensembl Gene ENSG00000102804
Encoded Proteins
TSC22 domain family, member 1
TSC22 domain family, member 1
TSC22 domain family, member 1
TSC22 domain family, member 1
TSC22 domain family, member 1
TSC22 domain family, member 1
TSC22 domain family, member 1
TSC22 domain family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:44432143-44577147
Strand Reverse strand
Band q14.11
Transcripts
ENST00000261489 ENSP00000261489
ENST00000458659 ENSP00000397435
ENST00000437455
ENST00000496314
ENST00000487881
ENST00000496838
ENST00000472477 ENSP00000419864
ENST00000486464 ENSP00000417476
ENST00000460842
ENST00000493016 ENSP00000418739
ENST00000501704 ENSP00000437414
ENST00000611198 ENSP00000481585
ENST00000622051 ENSP00000483407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
Experimentally validated
Total 127 [view]
Protein-Protein 127 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436383 Hs.713129 Hs.713154
RefSeq NM_001243797 NM_001243798 NM_001243799 NM_006022 NM_183422 XM_006719887
HUGO
OMIM
CCDS CCDS31966 CCDS58291 CCDS73565 CCDS9392
HPRD 07414
IMGT
EMBL
GenPept
RNA Seq Atlas