Homo sapiens Gene: RAD54B
Summary
InnateDB Gene IDBG-28912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD54B
Gene Name RAD54 homolog B (S. cerevisiae)
Synonyms RDH54;
Species Homo sapiens
Ensembl Gene ENSG00000197275
Encoded Proteins
RAD54 homolog B (S. cerevisiae)
RAD54 homolog B (S. cerevisiae)
RAD54 homolog B (S. cerevisiae)
RAD54 homolog B (S. cerevisiae)
RAD54 homolog B (S. cerevisiae)
RAD54 homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94371960-94475109
Strand Reverse strand
Band q22.1
Transcripts
ENST00000336148 ENSP00000336606
ENST00000297592 ENSP00000430153
ENST00000519348
ENST00000518358
ENST00000463267 ENSP00000430808
ENST00000523192
ENST00000518998 ENSP00000430570
ENST00000523839 ENSP00000428554
ENST00000611249 ENSP00000483397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006200 ATP catabolic process
GO:0006312 mitotic recombination
GO:0007131 reciprocal meiotic recombination
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y620
TrEMBL
UniProt Splice Variant
Entrez Gene 25788
UniGene Hs.30561
RefSeq NM_001205262 NM_012415 NM_001205263
HUGO HGNC:17228
OMIM 604289
CCDS CCDS56546 CCDS6262 CCDS75768
HPRD 09966
IMGT
EMBL AC023632 AF112481 AL523600 AP003534 BC001965
GenPept AAD34331 AAH01965
RNA Seq Atlas 25788