InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD54B

Summary

InnateDB Protein

IDBP-28914.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD54B

Protein Name

RAD54 homolog B (S. cerevisiae)

Synonyms

RDH54;

Species

Homo sapiens

Ensembl Protein

ENSP00000336606

InnateDB Gene

IDBG-28912 (RAD54B)

Protein Structure

UniProt Annotation

Function

Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. {ECO:0000269PubMed:11782437, ECO:0000269PubMed:11884632}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate, ovary and colon. {ECO:0000269PubMed:10362364}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	27 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003724	RNA helicase activity
GO:0005524	ATP binding
GO:0015616	DNA translocase activity
GO:0016787	hydrolase activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006312	mitotic recombination
GO:0007131	reciprocal meiotic recombination
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021006 Histone deacetylase complex, subunit 2/3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF04851
PF11496

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y620