Homo sapiens Gene: NUDT9
Summary
InnateDB Gene IDBG-29004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT9
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170502
Encoded Proteins
nudix (nucleoside diphosphate linked moiety X)-type motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:87422582-87459454
Strand Forward strand
Band q22.1
Transcripts
ENST00000302174 ENSP00000303575
ENST00000440591 ENSP00000410270
ENST00000512216 ENSP00000424702
ENST00000514345
ENST00000473942 ENSP00000421811
ENST00000514227
ENST00000502933 ENSP00000422232
ENST00000515371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0019144 ADP-sugar diphosphatase activity
GO:0043262 adenosine-diphosphatase activity
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0034656 nucleobase-containing small molecule catabolic process
GO:0044281 small molecule metabolic process
GO:0046032 ADP catabolic process
GO:0046709 IDP catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H7C386
UniProt Splice Variant
Entrez Gene 53343
UniGene Hs.149500
RefSeq NM_001248011 NM_024047 NM_198038
HUGO HGNC:8056
OMIM 606022
CCDS CCDS3620 CCDS3621
HPRD 09353
IMGT
EMBL AC112250
GenPept
RNA Seq Atlas 53343