Version 5.4
Homo sapiens Gene: NUDT9
Summary
InnateDB Gene IDBG-29004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT9
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170502
Encoded Proteins
IDBP-29006
nudix (nucleoside diphosphate linked moiety X)-type motif 9
IDBP-373945
nudix (nucleoside diphosphate linked moiety X)-type motif 9
IDBP-482994
nudix (nucleoside diphosphate linked moiety X)-type motif 9
IDBP-481972
nudix (nucleoside diphosphate linked moiety X)-type motif 9
IDBP-481311
nudix (nucleoside diphosphate linked moiety X)-type motif 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:87422582-87459454
Strand Forward strand
Band q22.1
Transcripts
ENST00000302174 ENSP00000303575
ENST00000440591 ENSP00000410270
ENST00000512216 ENSP00000424702
ENST00000514345
ENST00000473942 ENSP00000421811
ENST00000514227
ENST00000502933 ENSP00000422232
ENST00000515371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0019144 ADP-sugar diphosphatase activity
GO:0043262 adenosine-diphosphatase activity
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0034656 nucleobase-containing small molecule catabolic process
GO:0044281 small molecule metabolic process
GO:0046032 ADP catabolic process
GO:0046709 IDP catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029310
View Gene Order
ENSBTAG00000011354
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.149500
RefSeq NM_001248011 NM_024047 NM_198038
HUGO
OMIM
CCDS CCDS3620 CCDS3621
HPRD 09353
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca