Homo sapiens Gene: CCNE2
Summary
InnateDB Gene IDBG-29174.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNE2
Gene Name cyclin E2
Synonyms CYCE2;
Species Homo sapiens
Ensembl Gene ENSG00000175305
Encoded Proteins
cyclin E2
cyclin E2
cyclin E2
cyclin E2
cyclin E2
cyclin E2
cyclin E2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94879770-94896678
Strand Reverse strand
Band q22.1
Transcripts
ENST00000308108 ENSP00000309181
ENST00000396133 ENSP00000379437
ENST00000520509 ENSP00000429089
ENST00000524224 ENSP00000430060
ENST00000523476
ENST00000521809 ENSP00000428988
ENST00000519889 ENSP00000430875
ENST00000517487
ENST00000611101 ENSP00000479777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901 protein kinase binding
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006270 DNA replication initiation
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
p53-Dependent G1 DNA Damage Response pathway
Cellular Senescence pathway
Cyclin E associated events during G1/S transition pathway
G0 and Early G1 pathway
Cell Cycle, Mitotic pathway
G1/S DNA Damage Checkpoints pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Cell Cycle Checkpoints pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Prostate cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.521693
RefSeq NM_057749
HUGO
OMIM
CCDS CCDS6264
HPRD 04801
IMGT
EMBL
GenPept
RNA Seq Atlas