InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNE2

Summary

InnateDB Protein

IDBP-475833.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNE2

Protein Name

cyclin E2

Synonyms

CYCE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000429089

InnateDB Gene

IDBG-29174 (CCNE2)

Protein Structure

UniProt Annotation

Function

Essential for the control of the cell cycle at the late G1 and early S phase.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9840943}.

Disease Associations

Tissue Specificity

According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	protein kinase binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006270	DNA replication initiation
GO:0051301	cell division
GO:0051726	regulation of cell cycle