Homo sapiens Gene: POLK
Summary
InnateDB Gene IDBG-29209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLK
Gene Name polymerase (DNA directed) kappa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122008
Encoded Proteins
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
polymerase (DNA directed) kappa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:75511756-75601144
Strand Forward strand
Band q13.3
Transcripts
ENST00000241436 ENSP00000241436
ENST00000503479 ENSP00000421997
ENST00000506928
ENST00000510815 ENSP00000422094
ENST00000505774 ENSP00000421879
ENST00000514296 ENSP00000425208
ENST00000515295 ENSP00000424174
ENST00000508867
ENST00000514141 ENSP00000423526
ENST00000504026 ENSP00000425075
ENST00000511527 ENSP00000420997
ENST00000505975 ENSP00000424859
ENST00000508526 ENSP00000426853
ENST00000509126 ENSP00000423532
ENST00000507073
ENST00000505069
ENST00000502567
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006297 nucleotide-excision repair, DNA gap filling
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL D6RAI7
UniProt Splice Variant
Entrez Gene 51426
UniGene Hs.135756 Hs.593188 Hs.593825 Hs.604847 Hs.732105
RefSeq NM_016218
HUGO HGNC:9183
OMIM 605650
CCDS CCDS4030
HPRD 09291
IMGT
EMBL AC010245 AC026424 AC116341
GenPept
RNA Seq Atlas 102725405 51426