Version 5.4
Homo sapiens Gene: GDF6
Summary
InnateDB Gene IDBG-29375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDF6
Gene Name growth differentiation factor 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156466
Encoded Proteins
IDBP-29377
growth differentiation factor 6
IDBP-811820
growth differentiation factor 6
IDBP-811822
growth differentiation factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:96142330-96160792
Strand Reverse strand
Band q22.1
Transcripts
ENST00000287020 ENSP00000287020
ENST00000621429 ENSP00000483711
ENST00000620978 ENSP00000480170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006915 apoptotic process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0040007 growth
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:1990009 retinal cell apoptotic process
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051279
View Gene Order
ENSBTAG00000007687
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.492277
RefSeq NM_001001557
HUGO
OMIM
CCDS CCDS34926
HPRD 11002
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca