Mus musculus Gene: Gdf6
Summary
InnateDB Gene IDBG-129105.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdf6
Gene Name growth differentiation factor 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051279
Encoded Proteins
growth differentiation factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156466:
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:9844372-9862345
Strand Forward strand
Band A1
Transcripts
ENSMUST00000057613 ENSMUSP00000062884
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006915 apoptotic process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0040007 growth
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:1990009 retinal cell apoptotic process
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
TGF-beta signaling pathway pathway
INOH
GPCR signaling pathway
BMP2 signaling pathway
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
TGF-beta signaling pathway pathway
INOH
GPCR signaling pathway
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P43028
TrEMBL A2AII0
UniProt Splice Variant
Entrez Gene 242316
UniGene Mm.302555
RefSeq NM_013526
OMIM
CCDS CCDS17960
HPRD
IMGT
MGI ID MGI:95689
MGI Symbol Gdf6
EMBL AJ537425 BC141339 BC141340 CH466538 U08338
GenPept AAA18779 AAI41340 AAI41341 CAD60935 EDL05665
RNA Seq Atlas 242316