Homo sapiens Gene: TAF10
Summary
InnateDB Gene IDBG-29432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF10
Gene Name TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Synonyms TAF2A; TAF2H; TAFII30;
Species Homo sapiens
Ensembl Gene ENSG00000166337
Encoded Proteins
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6606296-6612667
Strand Reverse strand
Band p15.4
Transcripts
ENST00000299424 ENSP00000299424
ENST00000527248 ENSP00000480402
ENST00000531760
ENST00000532344
ENST00000616342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 97 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030331 estrogen receptor binding
GO:0070063 RNA polymerase binding
Biological Process
GO:0006325 chromatin organization
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
GO:0016578 histone deubiquitination
GO:0043966 histone H3 acetylation
GO:0051260 protein homooligomerization
Cellular Component
GO:0000125 PCAF complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005737 cytoplasm
GO:0030914 STAGA complex
GO:0033276 transcription factor TFTC complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
RNA Polymerase II Transcription Initiation pathway
Late Phase of HIV Life Cycle pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
RNA Polymerase II Pre-transcription Events pathway
Chromatin organization pathway
Transcription of the HIV genome pathway
Chromatin modifying enzymes pathway
HIV Infection pathway
HIV Transcription Initiation pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
KEGG
Basal transcription factors pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional activation
C-MYC pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5158
RefSeq NM_006284
HUGO
OMIM
CCDS CCDS7769
HPRD 15972
IMGT
EMBL
GenPept
RNA Seq Atlas