InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF10

Summary

InnateDB Gene

IDBG-29432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF10

Gene Name

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa

Synonyms

TAF2A; TAF2H; TAFII30

Species

Homo sapiens

Ensembl Gene

ENSG00000166337

Encoded Proteins

IDBP-29434

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa

IDBP-808931

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:6606296-6612667

Strand

Reverse strand

Band

p15.4

Transcripts

ENST00000299424	ENSP00000299424
ENST00000527248	ENSP00000480402
ENST00000531760
ENST00000532344
ENST00000616342

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	97 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0070063	RNA polymerase binding

Biological Process

GO:0006325	chromatin organization
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0016578	histone deubiquitination
GO:0043966	histone H3 acetylation
GO:0051260	protein homooligomerization

Cellular Component

GO:0000125	PCAF complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0048471	perinuclear region of cytoplasm