InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F2RL2

Summary

InnateDB Gene

IDBG-29585.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F2RL2

Gene Name

coagulation factor II (thrombin) receptor-like 2

Synonyms

PAR-3; PAR3

Species

Homo sapiens

Ensembl Gene

ENSG00000164220

Encoded Proteins

IDBP-29587

coagulation factor II (thrombin) receptor-like 2

IDBP-478613

coagulation factor II (thrombin) receptor-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18264801

F2RL2 is able to signal autonomously to induce IL8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses.

Entrez Gene

Summary

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:76615482-76623434

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000296641	ENSP00000296641
ENST00000504899	ENSP00000426703

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015057	thrombin receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009611	response to wounding
GO:0030168	platelet activation
GO:0045087	innate immune response (InnateDB)
GO:0070493	thrombin receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane