InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: F2RL2

Summary

InnateDB Protein

IDBP-29587.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F2RL2

Protein Name

coagulation factor II (thrombin) receptor-like 2

Synonyms

PAR-3; PAR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000296641

InnateDB Gene

IDBG-29585 (F2RL2)

Protein Structure

UniProt Annotation

Function

Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. {ECO:0000269PubMed:10079109}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. {ECO:0000269PubMed:9614115}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015057	thrombin receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009611	response to wounding
GO:0030168	platelet activation
GO:0045087	innate immune response (InnateDB)
GO:0070493	thrombin receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003912 Protease-activated receptor
IPR003943 Protease-activated receptor 3
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01428
PR01429

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00254