Version 5.4
Homo sapiens Gene: MTDH
Summary
InnateDB Gene IDBG-29612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTDH
Gene Name metadherin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147649
Encoded Proteins
IDBP-29614
metadherin
IDBP-484448
metadherin
IDBP-480784
metadherin
IDBP-478376
metadherin
IDBP-473764
metadherin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:97644179-97728770
Strand Forward strand
Band q22.1
Transcripts
ENST00000336273 ENSP00000338235
ENST00000519934 ENSP00000428168
ENST00000522313 ENSP00000428703
ENST00000519293 ENSP00000429289
ENST00000521933 ENSP00000429642
ENST00000522104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003713 transcription coactivator activity
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0010508 positive regulation of autophagy
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766 positive regulation of angiogenesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0070830 tight junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016604 nuclear body
GO:0031965 nuclear membrane
GO:0046581 intercellular canaliculus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022255
View Gene Order
ENSBTAG00000003098
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.377155 Hs.604038 Hs.617671
RefSeq NM_178812 XM_005251100
HUGO
OMIM
CCDS CCDS6274
HPRD 17459
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca