InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTDH

Summary

InnateDB Protein

IDBP-29614.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTDH

Protein Name

metadherin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000338235

InnateDB Gene

IDBG-29612 (MTDH)

Protein Structure

UniProt Annotation

Function

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269PubMed:15927426, ECO:0000269PubMed:16452207, ECO:0000269PubMed:18316612, ECO:0000269PubMed:19111877}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. {ECO:0000269PubMed:15927426}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003713	transcription coactivator activity
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0010508	positive regulation of autophagy
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766	positive regulation of angiogenesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0070830	tight junction assembly

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016604	nuclear body
GO:0031965	nuclear membrane
GO:0046581	intercellular canaliculus
GO:0048471	perinuclear region of cytoplasm