Version 5.4
Homo sapiens Gene: USP17L2
Summary
InnateDB Gene IDBG-296982.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP17L2
Gene Name ubiquitin specific peptidase 17-like family member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000223443
Encoded Proteins
IDBP-7784
ubiquitin specific peptidase 17-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:12137168-12139077
Strand Reverse strand
Band p23.1
Transcripts
ENST00000333796 ENSP00000333329
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000075 cell cycle checkpoint
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0007093 mitotic cell cycle checkpoint
GO:0010955 negative regulation of protein processing
GO:0016579 protein deubiquitination
GO:0030334 regulation of cell migration
GO:0031064 negative regulation of histone deacetylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0034261 negative regulation of Ras GTPase activity
GO:0042127 regulation of cell proliferation
GO:0042981 regulation of apoptotic process
GO:0050691 regulation of defense response to virus by host
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0071586 CAAX-box protein processing
GO:0090315 negative regulation of protein targeting to membrane
GO:1900027 regulation of ruffle assembly
GO:1900245 positive regulation of MDA-5 signaling pathway
GO:1900246 positive regulation of RIG-I signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q6R6M4
TrEMBL
UniProt Splice Variant
Entrez Gene 377630
UniGene Hs.531448
RefSeq NM_201402
HUGO HGNC:34434
OMIM 610186
CCDS CCDS43713
HPRD
IMGT
EMBL AC130366 AY509884
GenPept AAR91701
RNA Seq Atlas 377630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca