InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP17L2

Summary

InnateDB Protein

IDBP-7784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP17L2

Protein Name

ubiquitin specific peptidase 17-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333329

InnateDB Gene

IDBG-296982 (USP17L2)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269PubMed:14699124, ECO:0000269PubMed:17109758, ECO:0000269PubMed:19188362, ECO:0000269PubMed:20147298, ECO:0000269PubMed:20228808, ECO:0000269PubMed:20368735, ECO:0000269PubMed:20388806, ECO:0000269PubMed:21239494, ECO:0000269PubMed:21448158}.

Subcellular Localization

Nucleus. Endoplasmic reticulum.

Disease Associations

Tissue Specificity

Broadly expressed. {ECO:0000269PubMed:14699124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000075	cell cycle checkpoint
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006915	apoptotic process
GO:0007093	mitotic cell cycle checkpoint
GO:0010955	negative regulation of protein processing
GO:0016579	protein deubiquitination
GO:0030334	regulation of cell migration
GO:0031064	negative regulation of histone deacetylation
GO:0032321	positive regulation of Rho GTPase activity
GO:0034261	negative regulation of Ras GTPase activity
GO:0042127	regulation of cell proliferation
GO:0042981	regulation of apoptotic process
GO:0050691	regulation of defense response to virus by host
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:0071586	CAAX-box protein processing
GO:0090315	negative regulation of protein targeting to membrane
GO:1900027	regulation of ruffle assembly
GO:1900245	positive regulation of MDA-5 signaling pathway
GO:1900246	positive regulation of RIG-I signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006861 Hyaluronan/mRNA-binding protein
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF04774

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6R6M4

PhosphoSite