Homo sapiens Gene: HERC5
Summary
InnateDB Gene IDBG-29776.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC5
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138646
Encoded Proteins
hect domain and RLD 5
hect domain and RLD 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
HERC5 positively regulates the innate antiviral responses by sustaining IRF3 activation via a novel post-translational modification, ISGylation.
Entrez Gene
Summary This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88457117-88506163
Strand Forward strand
Band q22.1
Transcripts
ENST00000264350 ENSP00000264350
ENST00000508695
ENST00000508159 ENSP00000424129
ENST00000510223
ENST00000502913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0042296 ISG15 ligase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0032020 ISG15-protein conjugation
GO:0032480 negative regulation of type I interferon production
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050688 regulation of defense response to virus
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon Signaling pathway
Immune System pathway
ISG15 antiviral mechanism pathway
Negative regulators of RIG-I/MDA5 signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.26663
RefSeq NM_016323
HUGO
OMIM
CCDS CCDS3630
HPRD 10502
IMGT
EMBL
GenPept
RNA Seq Atlas