InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HERC5

Summary

InnateDB Gene

IDBG-29776.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERC5

Gene Name

HECT and RLD domain containing E3 ubiquitin protein ligase 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000138646

Encoded Proteins

IDBP-29778

hect domain and RLD 5

IDBP-481927

hect domain and RLD 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20308324

HERC5 positively regulates the innate antiviral responses by sustaining IRF3 activation via a novel post-translational modification, ISGylation.

Entrez Gene

Summary

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:88457117-88506163

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000264350	ENSP00000264350
ENST00000508695
ENST00000508159	ENSP00000424129
ENST00000510223
ENST00000502913

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0042296	ISG15 ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0032020	ISG15-protein conjugation
GO:0032480	negative regulation of type I interferon production
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050688	regulation of defense response to virus
GO:0051607	defense response to virus