InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XCR1

Summary

InnateDB Gene

IDBG-30030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XCR1

Gene Name

chemokine (C motif) receptor 1

Synonyms

CCXCR1; GPR5

Species

Homo sapiens

Ensembl Gene

ENSG00000173578

Encoded Proteins

IDBP-30032

chemokine (C motif) receptor 1

IDBP-238529

chemokine (C motif) receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:46017024-46027742

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000309285	ENSP00000310405
ENST00000395946	ENSP00000379277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0034097	response to cytokine
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000060509

View Gene Order

ENSBTAG00000020019

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P46094

TrEMBL

Q689E2

UniProt Splice Variant

Entrez Gene

2829

UniGene

Hs.128375 Hs.248116

RefSeq

NM_001024644 NM_005283

HUGO

HGNC:1625

OMIM

600552

CCDS

CCDS2736

HPRD

02774

IMGT

EMBL

AB189434 AB189435 AC099782 AC133140 AY275469 BC069075 BC069589 L36149

GenPept

AAA62837 AAH69075 AAH69589 AAP32301 BAD38891 BAD38892

RNA Seq Atlas

2829