Version 5.4
Homo sapiens Protein: XCR1
Summary
InnateDB Protein IDBP-30032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XCR1
Protein Name chemokine (C motif) receptor 1
Synonyms CCXCR1; GPR5;
Species Homo sapiens
Ensembl Protein ENSP00000310405
InnateDB Gene IDBG-30030 (XCR1)
Protein Structure
UniProt Annotation
Function Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0034097 response to cytokine
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR005393 XC chemokine receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00657
PR00425
PR01568
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46094
PhosphoSite PhosphoSite-P46094
TrEMBL Q689E2
UniProt Splice Variant
Entrez Gene 2829
UniGene Hs.248116
RefSeq NP_005274
HUGO HGNC:1625
OMIM 600552
CCDS CCDS2736
HPRD 02774
IMGT
EMBL AB189434 AB189435 AC099782 AC133140 AY275469 BC069075 BC069589 L36149
GenPept AAA62837 AAH69075 AAH69589 AAP32301 BAD38891 BAD38892

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca