Version 5.4
Homo sapiens Gene: LTA
Summary
InnateDB Gene IDBG-302490.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTA
Gene Name lymphotoxin alpha (TNF superfamily, member 1)
Synonyms LT; TNFB; TNFSF1
Species Homo sapiens
Ensembl Gene ENSG00000226979
Encoded Proteins
IDBP-371524
lymphotoxin alpha (TNF superfamily, member 1)
IDBP-371535
lymphotoxin alpha (TNF superfamily, member 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin\'s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31572054-31574324
Strand Forward strand
Band p21.33
Transcripts
ENST00000454783 ENSP00000403495
ENST00000418386 ENSP00000413450
ENST00000489638
ENST00000471842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007584 response to nutrient
GO:0032496 response to lipopolysaccharide
GO:0032729 positive regulation of interferon-gamma production
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044130 negative regulation of growth of symbiont in host
GO:0048147 negative regulation of fibroblast proliferation
GO:0048535 lymph node development
GO:0050830 defense response to Gram-positive bacterium
GO:0060252 positive regulation of glial cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024402
View Gene Order
ENSBTAG00000000016
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04940
Type I diabetes mellitus pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.36
RefSeq NM_000595 NM_001159740
HUGO
OMIM
CCDS CCDS4701
HPRD 01084
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca