InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LTA

Summary

InnateDB Protein

IDBP-371524.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTA

Protein Name

lymphotoxin alpha (TNF superfamily, member 1)

Synonyms

LT; TNFB; TNFSF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000403495

InnateDB Gene

IDBG-302490 (LTA)

Protein Structure

UniProt Annotation

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Subcellular Localization

Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.

Disease Associations

Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269PubMed:12746914}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006915	apoptotic process
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007584	response to nutrient
GO:0032496	response to lipopolysaccharide
GO:0032729	positive regulation of interferon-gamma production
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0048147	negative regulation of fibroblast proliferation
GO:0048535	lymph node development
GO:0050830	defense response to Gram-positive bacterium
GO:0060252	positive regulation of glial cell proliferation