Version 5.4
Homo sapiens Gene: CRTC3
Summary
InnateDB Gene IDBG-30305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRTC3
Gene Name CREB regulated transcription coactivator 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140577
Encoded Proteins
IDBP-30307
CREB regulated transcription coactivator 3
IDBP-380414
CREB regulated transcription coactivator 3
IDBP-583292
CREB regulated transcription coactivator 3
IDBP-594993
CREB regulated transcription coactivator 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90529925-90645345
Strand Forward strand
Band q26.1
Transcripts
ENST00000268184 ENSP00000268184
ENST00000420329 ENSP00000416573
ENST00000560098 ENSP00000452640
ENST00000561218
ENST00000558619
ENST00000560927
ENST00000561119
ENST00000558005 ENSP00000452676
ENST00000561290
ENST00000558496
ENST00000561255
ENST00000560047
ENST00000560320
ENST00000558167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016032 viral process
GO:0032793 positive regulation of CREB transcription factor activity
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050995 negative regulation of lipid catabolic process
GO:0051289 protein homotetramerization
GO:0097009 energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030527
View Gene Order
ENSBTAG00000010915
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567572 Hs.618881 Hs.739395
RefSeq NM_001042574 NM_022769 XM_005254968
HUGO
OMIM
CCDS CCDS32331 CCDS45348
HPRD 13384
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca