Version 5.4
Homo sapiens Protein: CRTC3
Summary
InnateDB Protein IDBP-30307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRTC3
Protein Name CREB regulated transcription coactivator 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000268184
InnateDB Gene IDBG-30305 (CRTC3)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269PubMed:14506290, ECO:0000269PubMed:15454081, ECO:0000269PubMed:15466468, ECO:0000269PubMed:16817901, ECO:0000269PubMed:16980408, ECO:0000269PubMed:17210223, ECO:0000269PubMed:17644518}.
Subcellular Localization Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
Disease Associations
Tissue Specificity Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269PubMed:14536081, ECO:0000269PubMed:16980408}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016032 viral process
GO:0032793 positive regulation of CREB transcription factor activity
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050995 negative regulation of lipid catabolic process
GO:0051289 protein homotetramerization
GO:0097009 energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UUV7
PhosphoSite PhosphoSite-Q6UUV7
TrEMBL
UniProt Splice Variant
Entrez Gene 64784
UniGene Hs.739395
RefSeq NP_073606
HUGO HGNC:26148
OMIM 608986
CCDS CCDS32331
HPRD 13384
IMGT
EMBL AC021422 AC103739 AK025521 AK090443 AY360173 BC074730 BC074731
GenPept AAH74730 AAH74731 AAQ98858 BAB15160 BAC03424

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca