Version 5.4
Homo sapiens Gene: FURIN
Summary
InnateDB Gene IDBG-30430.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FURIN
Gene Name furin (paired basic amino acid cleaving enzyme)
Synonyms FUR; PACE; PCSK3; SPC1
Species Homo sapiens
Ensembl Gene ENSG00000140564
Encoded Proteins
IDBP-30432
furin (paired basic amino acid cleaving enzyme)
IDBP-595572
furin (paired basic amino acid cleaving enzyme)
IDBP-600490
furin (paired basic amino acid cleaving enzyme)
IDBP-599800
furin (paired basic amino acid cleaving enzyme)
IDBP-806557
furin (paired basic amino acid cleaving enzyme)
IDBP-806558
furin (paired basic amino acid cleaving enzyme)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90868592-90883458
Strand Forward strand
Band q26.1
Transcripts
ENST00000268171 ENSP00000268171
ENST00000559353 ENSP00000452730
ENST00000560824 ENSP00000453212
ENST00000558794 ENSP00000453942
ENST00000560018
ENST00000610579 ENSP00000484952
ENST00000618099 ENSP00000483552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0048406 nerve growth factor binding
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0009966 regulation of signal transduction
GO:0010951 negative regulation of endopeptidase activity
GO:0016032 viral process
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0019082 viral protein processing
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0032455 nerve growth factor processing
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902 nerve growth factor production
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032940 secretion by cell
GO:0042176 regulation of protein catabolic process
GO:0043043 peptide biosynthetic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030530
View Gene Order
ENSBTAG00000002939
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_11062
NGF processing pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_16888
Signaling by PDGF pathway
REACT_150366
Elastic fibre formation pathway
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_150401
Collagen degradation pathway
REACT_733
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_1132
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_111057
Signaling by NODAL pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_22161
Post-translational protein modification pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_118779
Extracellular matrix organization pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_163660
Synthesis and processing of ENV and VPU pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_228211
Uptake and actions of bacterial toxins pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_17015
Metabolism of proteins pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_6256
HIV Life Cycle pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_6185
HIV Infection pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_6818
Assembly Of The HIV Virion pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_228255
Uptake and function of anthrax toxins pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
INOH website
Notch signaling pathway pathway
PID NCI
glypican_3pathway
Glypican 3 network
p75ntrpathway
p75(NTR)-mediated signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
notch_pathway
Notch signaling pathway
Cross-References
SwissProt P09958
TrEMBL A0A024RC70 H0YKB2 H0YNB5
UniProt Splice Variant
Entrez Gene 5045
UniGene Hs.513153 Hs.701745
RefSeq NM_002569 NM_001289823 NM_001289824
HUGO HGNC:8568
OMIM 136950
CCDS CCDS10364
HPRD 00653
IMGT
EMBL AC124248 BC012181 CH471101 X04329 X15723 X17094
GenPept AAH12181 CAA27860 CAA33745 CAA34948 EAX02111 EAX02112
RNA Seq Atlas 5045

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca