InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FURIN

Summary

InnateDB Protein

IDBP-30432.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FURIN

Protein Name

furin (paired basic amino acid cleaving enzyme)

Synonyms

FUR; PACE; PCSK3; SPC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000268171

InnateDB Gene

IDBG-30430 (FURIN)

Protein Structure

UniProt Annotation

Function

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. {ECO:0000269PubMed:7690548}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.

Disease Associations

Tissue Specificity

Seems to be expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0008233	peptidase activity
GO:0042277	peptide binding
GO:0046872	metal ion binding
GO:0048406	nerve growth factor binding

Biological Process

GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008283	cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0016032	viral process
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0032455	nerve growth factor processing
GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902	nerve growth factor production
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:0032940	secretion by cell
GO:0042176	regulation of protein catabolic process
GO:0043043	peptide biosynthetic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0052548	regulation of endopeptidase activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005796	Golgi lumen
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt