Homo sapiens Gene: ADCY7
Summary
InnateDB Gene IDBG-30450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY7
Gene Name adenylate cyclase 7
Synonyms AC7;
Species Homo sapiens
Ensembl Gene ENSG00000121281
Encoded Proteins
adenylate cyclase 7
adenylate cyclase 7
adenylate cyclase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. [provided by RefSeq, Jul 2008]
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:50246137-50318135
Strand Forward strand
Band q12.1
Transcripts
ENST00000254235 ENSP00000254235
ENST00000394697 ENSP00000378187
ENST00000537579 ENSP00000437788
ENST00000568930
ENST00000567277 ENSP00000455670
ENST00000568933
ENST00000566761 ENSP00000454301
ENST00000562623
ENST00000570187
ENST00000564965 ENSP00000460636
ENST00000566433 ENSP00000457409
ENST00000563677
ENST00000569265 ENSP00000460018
ENST00000568731
ENST00000564044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060135 maternal process involved in female pregnancy
GO:0071361 cellular response to ethanol
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by FGFR in disease pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Adenylate cyclase activating pathway pathway
CaM pathway pathway
Signalling by NGF pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Phospholipase C-mediated cascade pathway
Adenylate cyclase inhibitory pathway pathway
DAP12 signaling pathway
Neuronal System pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
GABA receptor activation pathway
Glucagon signaling in metabolic regulation pathway
PLC-gamma1 signalling pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
DAG and IP3 signaling pathway
PKA activation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Immune System pathway
Downstream signal transduction pathway
G alpha (z) signalling events pathway
GABA B receptor activation pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Signaling by PDGF pathway
PKA activation in glucagon signalling pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
PLCG1 events in ERBB2 signaling pathway
Ca-dependent events pathway
Calmodulin induced events pathway
Aquaporin-mediated transport pathway
Disease pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Purine metabolism pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Gap junction pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Bile secretion pathway
Dilated cardiomyopathy pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL F5H4D1 I3L3Q5
UniProt Splice Variant
Entrez Gene 113
UniGene Hs.708878
RefSeq NM_001286057 XM_005255786 NM_001114 XM_005255785 XM_006721128 XM_005255784 XM_005255783 XM_005255782 XM_005255780 XM_005255781 XM_005255779
HUGO HGNC:238
OMIM 600385
CCDS CCDS73882 CCDS10741
HPRD 02663
IMGT
EMBL AC007597
GenPept
RNA Seq Atlas 113