Homo sapiens Gene: GPX1
Summary
InnateDB Gene IDBG-305033.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX1
Gene Name glutathione peroxidase 1
Synonyms GPXD; GSHPX1;
Species Homo sapiens
Ensembl Gene ENSG00000233276
Encoded Proteins
glutathione peroxidase 1
glutathione peroxidase 1
glutathione peroxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49357176-49358600
Strand Reverse strand
Band p21.31
Transcripts
ENST00000419783 ENSP00000407375
ENST00000419349 ENSP00000391316
ENST00000496791
ENST00000620890 ENSP00000478837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0008430 selenium binding
GO:0017124 SH3 domain binding
GO:0043295 glutathione binding
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001659 temperature homeostasis
GO:0001885 endothelial cell development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0006144 purine nucleobase metabolic process
GO:0006195 purine nucleotide catabolic process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006749 glutathione metabolic process
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0006982 response to lipid hydroperoxide
GO:0007568 aging
GO:0007605 sensory perception of sound
GO:0008283 cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410 response to xenobiotic stimulus
GO:0009609 response to symbiotic bacterium
GO:0009611 response to wounding
GO:0009636 response to toxic substance
GO:0009650 UV protection
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010269 response to selenium ion
GO:0010332 response to gamma radiation
GO:0014070 response to organic cyclic compound
GO:0014902 myotube differentiation
GO:0018158 protein oxidation
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0032355 response to estradiol
GO:0033194 response to hydroperoxide
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0035094 response to nicotine
GO:0040029 regulation of gene expression, epigenetic
GO:0042311 vasodilation
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403 skeletal muscle tissue regeneration
GO:0043523 regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045444 fat cell differentiation
GO:0045454 cell redox homeostasis
GO:0048741 skeletal muscle fiber development
GO:0051450 myoblast proliferation
GO:0051593 response to folic acid
GO:0051702 interaction with symbiont
GO:0051897 positive regulation of protein kinase B signaling
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0060047 heart contraction
GO:0060055 angiogenesis involved in wound healing
GO:0061136 regulation of proteasomal protein catabolic process
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Purine metabolism pathway
Purine catabolism pathway
Detoxification of Reactive Oxygen Species pathway
Synthesis of 12-eicosatetraenoic acid derivatives pathway
Metabolism of nucleotides pathway
Metabolism pathway
Synthesis of 5-eicosatetraenoic acids pathway
Synthesis of 15-eicosatetraenoic acid derivatives pathway
KEGG
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
INOH
PID BIOCARTA
Cardiac protection against ros [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt P07203
TrEMBL A0A024R2T1 X5D926 X5DQZ7
UniProt Splice Variant
Entrez Gene 2876
UniGene
RefSeq NM_000581 NM_201397
HUGO HGNC:4553
OMIM 138320
CCDS CCDS43091 CCDS54582
HPRD
IMGT
EMBL AC121247 AY327818 BC000742 CH471055 KJ534852 KJ534853 M21304 M83094 X13709 X13710 Y00433 Y00483
GenPept AAA67540 AAA75389 AAH00742 AAP80181 AHW56492 AHW56493 CAA31992 CAA31993 CAA68491 CAB37833 EAW64976 EAW64977
RNA Seq Atlas 2876