InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPX1

Summary

InnateDB Gene

IDBG-305033.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPX1

Gene Name

glutathione peroxidase 1

Synonyms

GPXD; GSHPX1

Species

Homo sapiens

Ensembl Gene

ENSG00000233276

Encoded Proteins

IDBP-377185

glutathione peroxidase 1

IDBP-377186

glutathione peroxidase 1

IDBP-811874

glutathione peroxidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:49357176-49358600

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000419783	ENSP00000407375
ENST00000419349	ENSP00000391316
ENST00000496791
ENST00000620890	ENSP00000478837

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0008430	selenium binding
GO:0017124	SH3 domain binding
GO:0043295	glutathione binding
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001659	temperature homeostasis
GO:0001885	endothelial cell development
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006749	glutathione metabolic process
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0006982	response to lipid hydroperoxide
GO:0007568	aging
GO:0007605	sensory perception of sound
GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410	response to xenobiotic stimulus
GO:0009609	response to symbiotic bacterium
GO:0009611	response to wounding
GO:0009636	response to toxic substance
GO:0009650	UV protection
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0010269	response to selenium ion
GO:0010332	response to gamma radiation
GO:0014070	response to organic cyclic compound
GO:0014902	myotube differentiation
GO:0018158	protein oxidation
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0032355	response to estradiol
GO:0033194	response to hydroperoxide
GO:0033599	regulation of mammary gland epithelial cell proliferation
GO:0035094	response to nicotine
GO:0040029	regulation of gene expression, epigenetic
GO:0042311	vasodilation
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0043523	regulation of neuron apoptotic process
GO:0043534	blood vessel endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045444	fat cell differentiation
GO:0045454	cell redox homeostasis
GO:0048741	skeletal muscle fiber development
GO:0051450	myoblast proliferation
GO:0051593	response to folic acid
GO:0051702	interaction with symbiont
GO:0051897	positive regulation of protein kinase B signaling
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0060055	angiogenesis involved in wound healing
GO:0061136	regulation of proteasomal protein catabolic process
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway