Version 5.4
Homo sapiens Gene: RND1
Summary
InnateDB Gene IDBG-30511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RND1
Gene Name Rho family GTPase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172602
Encoded Proteins
IDBP-30513
Rho family GTPase 1
IDBP-603467
Rho family GTPase 1
IDBP-595519
Rho family GTPase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the Rho GTPase family, such as RND1, regulate the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998 [PubMed 9531558]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:48857145-48865898
Strand Reverse strand
Band q13.12
Transcripts
ENST00000309739 ENSP00000308461
ENST00000550607 ENSP00000447059
ENST00000548445
ENST00000553260
ENST00000551243 ENSP00000449045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007015 actin filament organization
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0015031 protein transport
GO:0016322 neuron remodeling
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054855
View Gene Order
ENSBTAG00000018773
Not yet available
Pathways
NETPATH
REACTOME
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.124940
RefSeq NM_014470
HUGO
OMIM
CCDS CCDS8771
HPRD 12357
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca