InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RND1

Summary

InnateDB Protein

IDBP-30513.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RND1

Protein Name

Rho family GTPase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308461

InnateDB Gene

IDBG-30511 (RND1)

Protein Structure

UniProt Annotation

Function

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. {ECO:0000269PubMed:11095956}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11940653}; Lipid-anchor {ECO:0000269PubMed:11940653}; Cytoplasmic side {ECO:0000269PubMed:11940653}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11940653}.

Disease Associations

Tissue Specificity

Mostly expressed in brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007015	actin filament organization
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0015031	protein transport
GO:0016322	neuron remodeling

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt