Homo sapiens Gene: DHPS
Summary
InnateDB Gene IDBG-30662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHPS
Gene Name deoxyhypusine synthase
Synonyms DHS; DS; MIG13;
Species Homo sapiens
Ensembl Gene ENSG00000095059
Encoded Proteins
deoxyhypusine synthase
deoxyhypusine synthase
deoxyhypusine synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12675717-12681902
Strand Reverse strand
Band p13.13
Transcripts
ENST00000210060 ENSP00000210060
ENST00000351660 ENSP00000221303
ENST00000595100 ENSP00000468889
ENST00000597152 ENSP00000472094
ENST00000601639 ENSP00000472330
ENST00000593400
ENST00000600639 ENSP00000469366
ENST00000596162 ENSP00000472348
ENST00000600510
ENST00000598850 ENSP00000471280
ENST00000595844
ENST00000600864 ENSP00000472096
ENST00000594424 ENSP00000471886
ENST00000600451 ENSP00000470754
ENST00000599481
ENST00000593473
ENST00000593432
ENST00000595912 ENSP00000468993
ENST00000596847
ENST00000593423 ENSP00000470188
ENST00000601537 ENSP00000472122
ENST00000598246 ENSP00000471466
ENST00000614126 ENSP00000482709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0034038 deoxyhypusine synthase activity
Biological Process
GO:0006412 translation
GO:0008284 positive regulation of cell proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050983 deoxyhypusine biosynthetic process from spermidine
GO:0051289 protein homotetramerization
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Hypusine synthesis from eIF5A-lysine pathway
Metabolism of proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.79064
RefSeq NM_001206974 NM_001930 NM_013406
HUGO
OMIM
CCDS CCDS12276 CCDS12277 CCDS59354
HPRD 02969
IMGT
EMBL
GenPept
RNA Seq Atlas