InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHPS

Summary

InnateDB Protein

IDBP-30664.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHPS

Protein Name

deoxyhypusine synthase

Synonyms

DHS; DS; MIG13;

Species

Homo sapiens

Ensembl Protein

ENSP00000210060

InnateDB Gene

IDBG-30662 (DHPS)

Protein Structure

UniProt Annotation

Function

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0034038	deoxyhypusine synthase activity

Biological Process

GO:0006412	translation
GO:0008284	positive regulation of cell proliferation
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0042102	positive regulation of T cell proliferation
GO:0042593	glucose homeostasis
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0050983	deoxyhypusine biosynthetic process from spermidine
GO:0051289	protein homotetramerization