InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARSB

Summary

InnateDB Gene

IDBG-30686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARSB

Gene Name

arylsulfatase B

Synonyms

ASB; G4S; MPS6

Species

Homo sapiens

Ensembl Gene

ENSG00000113273

Encoded Proteins

IDBP-30690

arylsulfatase B

IDBP-238102

arylsulfatase B

IDBP-473926

arylsulfatase B

IDBP-717860

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:78777209-78986087

Strand

Reverse strand

Band

q14.1

Transcripts

ENST00000264914	ENSP00000264914
ENST00000396151	ENSP00000379455
ENST00000521011
ENST00000521800
ENST00000521117	ENSP00000428611
ENST00000565165	ENSP00000456339

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003943	N-acetylgalactosamine-4-sulfatase activity
GO:0004065	arylsulfatase activity
GO:0008484	sulfuric ester hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006665	sphingolipid metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0006914	autophagy
GO:0007040	lysosome organization
GO:0007041	lysosomal transport
GO:0007417	central nervous system development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009268	response to pH
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030207	chondroitin sulfate catabolic process
GO:0043627	response to estrogen
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0051597	response to methylmercury

Cellular Component

GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005788	endoplasmic reticulum lumen
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome