Version 5.4
Homo sapiens Gene: VPS33B
Summary
InnateDB Gene IDBG-30774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS33B
Gene Name vacuolar protein sorting 33 homolog B (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184056
Encoded Proteins
IDBP-30778
vacuolar protein sorting 33 homolog B (yeast)
IDBP-594542
vacuolar protein sorting 33 homolog B (yeast)
IDBP-746240
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90998416-91022603
Strand Reverse strand
Band q26.1
Transcripts
ENST00000333371 ENSP00000327650
ENST00000557470
ENST00000535906 ENSP00000444053
ENST00000554660
ENST00000556096
ENST00000554264
ENST00000557358
ENST00000574755 ENSP00000460413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006904 vesicle docking involved in exocytosis
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032400 melanosome localization
GO:0032418 lysosome localization
GO:0061025 membrane fusion
GO:0070889 platelet alpha granule organization
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0030897 HOPS complex
GO:0031091 platelet alpha granule
GO:0031902 late endosome membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030534
View Gene Order
ENSBTAG00000000026
Not yet available
Cross-References
SwissProt Q9H267
TrEMBL B3KQF6 F5H008 G3V3F9
UniProt Splice Variant
Entrez Gene 26276
UniGene Hs.459366
RefSeq NM_001289148 NM_001289149 NM_018668 XM_005254888
HUGO HGNC:12712
OMIM 608552
CCDS CCDS10369 CCDS73783
HPRD
IMGT
EMBL AC068831 AF201694 AF308803 AK027754 AK074863 AL357472 BC016445 CH471101
GenPept AAF91174 AAG34680 AAH16445 BAB55345 BAG52018 CAB93109 EAX02140
RNA Seq Atlas 26276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca