InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS33B

Summary

InnateDB Protein

IDBP-30778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS33B

Protein Name

vacuolar protein sorting 33 homolog B (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000327650

InnateDB Gene

IDBG-30774 (VPS33B)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. {ECO:0000269PubMed:18474358}.

Subcellular Localization

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles.

Disease Associations

Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1) [MIM:208085]: A multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common. {ECO:0000269PubMed:15052268, ECO:0000269PubMed:18853461}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous; highly expressed in testis and low expression in the lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006904	vesicle docking involved in exocytosis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032400	melanosome localization
GO:0032418	lysosome localization
GO:0061025	membrane fusion
GO:0070889	platelet alpha granule organization

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0030897	HOPS complex
GO:0031091	platelet alpha granule
GO:0031902	late endosome membrane
GO:0048471	perinuclear region of cytoplasm