InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYCN

Summary

InnateDB Gene

IDBG-30973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYCN

Gene Name

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Synonyms

bHLHe37; MODED; N-myc; NMYC; ODED

Species

Homo sapiens

Ensembl Gene

ENSG00000134323

Encoded Proteins

IDBP-30975

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:15940564-15947007

Strand

Forward strand

Band

p24.3

Transcripts

ENST00000281043

ENSP00000281043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001502	cartilage condensation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0010942	positive regulation of cell death
GO:0030324	lung development
GO:0042733	embryonic digit morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048712	negative regulation of astrocyte differentiation
GO:0048754	branching morphogenesis of an epithelial tube
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037169

View Gene Order

ENSBTAG00000023372

Not yet available

Cross-References

SwissProt

P04198

TrEMBL

Q7Z7Q9 Q9UMQ5

UniProt Splice Variant

Entrez Gene

4613

UniGene

Hs.25960

RefSeq

NM_001293228 NM_001293233 NM_005378 XM_006711886

HUGO

HGNC:7559

OMIM

164840

CCDS

CCDS1687

HPRD

IMGT

EMBL

AC010145 AJ242956 BC002712 BT007384 CH471053 M13228 M13241 M18090 X02363 X03294 X03295 Y00664

GenPept

AAA36370 AAA36371 AAA59885 AAH02712 AAP36048 AAY14952 CAA27037 CAA27038 CAA68678 CAB37871 CAB44703 EAX00885 EAX00886 EAX00887 EAX00888

RNA Seq Atlas

4613