Mus musculus Gene: Mycn
Summary
InnateDB Gene IDBG-128962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mycn
Gene Name v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Synonyms bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1; Nmyc1;
Species Mus musculus
Ensembl Gene ENSMUSG00000037169
Encoded Proteins
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134323:
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:12936096-12941914
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000043396 ENSMUSP00000045993
ENSMUST00000130990 ENSMUSP00000114225
ENSMUST00000151534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001502 cartilage condensation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0010942 positive regulation of cell death
GO:0030324 lung development
GO:0042733 embryonic digit morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048704 embryonic skeletal system morphogenesis
GO:0048712 negative regulation of astrocyte differentiation
GO:0048754 branching morphogenesis of an epithelial tube
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P03966
TrEMBL Q3UII1 Q810L7
UniProt Splice Variant
Entrez Gene 18109
UniGene Mm.16469 Mm.400380
RefSeq NM_008709
OMIM
CCDS CCDS25818
HPRD
IMGT
MGI ID MGI:97357
MGI Symbol Mycn
EMBL AK146696 AK146913 BC049783 CH466582 M12731 M29208 M36277 X03919 X06993
GenPept AAA39788 AAA39830 AAA39833 AAH49783 BAE27366 BAE27525 CAA27557 EDK98450
RNA Seq Atlas 18109