InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mycn

Summary

InnateDB Gene

IDBG-128962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mycn

Gene Name

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Synonyms

bHLHe37; c-nmyc; N-myc; Nmyc; Nmyc-1; Nmyc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037169

Encoded Proteins

IDBP-128964

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

IDBP-542340

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134323:
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:12936096-12941914

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000043396	ENSMUSP00000045993
ENSMUST00000130990	ENSMUSP00000114225
ENSMUST00000151534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	8 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001502	cartilage condensation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0010942	positive regulation of cell death
GO:0030324	lung development
GO:0042733	embryonic digit morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048712	negative regulation of astrocyte differentiation
GO:0048754	branching morphogenesis of an epithelial tube
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000134323

View Gene Order

ENSBTAG00000023372

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.16469 Mm.400380

RefSeq

NM_008709

OMIM

CCDS

CCDS25818

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas