Version 5.4
Homo sapiens Gene: SLC7A8
Summary
InnateDB Gene IDBG-3104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A8
Gene Name solute carrier family 7 (amino acid transporter light chain, L system), member 8
Synonyms LAT2; LPI-PC1
Species Homo sapiens
Ensembl Gene ENSG00000092068
Encoded Proteins
IDBP-3106
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-3110
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-362087
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-362101
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-602503
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-603176
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-593584
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-601983
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-601243
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-806402
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-806405
solute carrier family 7 (amino acid transporter light chain, L system), member 8
IDBP-806410
solute carrier family 7 (amino acid transporter light chain, L system), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23125295-23183674
Strand Reverse strand
Band q11.2
Transcripts
ENST00000316902 ENSP00000320378
ENST00000339733 ENSP00000343949
ENST00000397310
ENST00000422941 ENSP00000416398
ENST00000453702 ENSP00000391577
ENST00000469263 ENSP00000435114
ENST00000529705 ENSP00000434345
ENST00000528860 ENSP00000435865
ENST00000528806
ENST00000528186
ENST00000532568
ENST00000524758 ENSP00000434352
ENST00000525062 ENSP00000436665
ENST00000618208 ENSP00000477662
ENST00000621729 ENSP00000480181
ENST00000617478 ENSP00000479318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015101 organic cation transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0019534 toxin transporter activity
GO:0042605 peptide antigen binding
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006520 cellular amino acid metabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0007596 blood coagulation
GO:0009636 response to toxic substance
GO:0015695 organic cation transport
GO:0015804 neutral amino acid transport
GO:0015807 L-amino acid transport
GO:0050900 leukocyte migration
GO:0055065 metal ion homeostasis
GO:0055085 transmembrane transport
GO:1901998 toxin transport
GO:1902475 L-alpha-amino acid transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022180
View Gene Order
ENSBTAG00000007415
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596643 Hs.722598 Hs.735363
RefSeq NM_001267036 NM_001267037 NM_012244 NM_182728
HUGO
OMIM
CCDS CCDS41924 CCDS58304 CCDS58305 CCDS9590
HPRD 11971
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca