Homo sapiens Gene: ADH5
Summary
InnateDB Gene IDBG-31067.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH5
Gene Name alcohol dehydrogenase 5 (class III), chi polypeptide
Synonyms ADH-3; ADHX; FALDH; FDH; GSH-FDH; GSNOR;
Species Homo sapiens
Ensembl Gene ENSG00000197894
Encoded Proteins
alcohol dehydrogenase 5 (class III), chi polypeptide
alcohol dehydrogenase 5 (class III), chi polypeptide
alcohol dehydrogenase 5 (class III), chi polypeptide
alcohol dehydrogenase 5 (class III), chi polypeptide
alcohol dehydrogenase 5 (class III), chi polypeptide
alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99070978-99088801
Strand Reverse strand
Band q23
Transcripts
ENST00000296412 ENSP00000296412
ENST00000512621
ENST00000512659 ENSP00000424650
ENST00000508511
ENST00000503130 ENSP00000427049
ENST00000502590 ENSP00000422119
ENST00000512991
ENST00000512604
ENST00000505652 ENSP00000421556
ENST00000508146
ENST00000507102
ENST00000502386 ENSP00000427026
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0005504 fatty acid binding
GO:0008270 zinc ion binding
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0018467 formaldehyde dehydrogenase activity
GO:0042803 protein homodimerization activity
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0003016 respiratory system process
GO:0006068 ethanol catabolic process
GO:0006069 ethanol oxidation
GO:0007568 aging
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0032496 response to lipopolysaccharide
GO:0045777 positive regulation of blood pressure
GO:0046294 formaldehyde catabolic process
GO:0051409 response to nitrosative stress
GO:0051775 response to redox state
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glycolysis / Gluconeogenesis pathway
Fatty acid degradation pathway
Tyrosine metabolism pathway
Retinol metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RAY0
UniProt Splice Variant
Entrez Gene 128
UniGene Hs.607419 Hs.714209 Hs.78989
RefSeq NM_000671
HUGO HGNC:253
OMIM 103710
CCDS CCDS47111
HPRD 00064
IMGT
EMBL AC019131
GenPept
RNA Seq Atlas 128