Version 5.4
Homo sapiens Gene: ADH5
Summary
InnateDB Gene IDBG-31067.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH5
Gene Name alcohol dehydrogenase 5 (class III), chi polypeptide
Synonyms ADH-3; ADHX; FALDH; FDH; GSH-FDH; GSNOR
Species Homo sapiens
Ensembl Gene ENSG00000197894
Encoded Proteins
IDBP-31069
alcohol dehydrogenase 5 (class III), chi polypeptide
IDBP-481487
alcohol dehydrogenase 5 (class III), chi polypeptide
IDBP-476690
alcohol dehydrogenase 5 (class III), chi polypeptide
IDBP-478966
alcohol dehydrogenase 5 (class III), chi polypeptide
IDBP-485261
alcohol dehydrogenase 5 (class III), chi polypeptide
IDBP-475621
alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99070978-99088801
Strand Reverse strand
Band q23
Transcripts
ENST00000296412 ENSP00000296412
ENST00000512621
ENST00000512659 ENSP00000424650
ENST00000508511
ENST00000503130 ENSP00000427049
ENST00000502590 ENSP00000422119
ENST00000512991
ENST00000512604
ENST00000505652 ENSP00000421556
ENST00000508146
ENST00000507102
ENST00000502386 ENSP00000427026
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0005504 fatty acid binding
GO:0008270 zinc ion binding
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0018467 formaldehyde dehydrogenase activity
GO:0042803 protein homodimerization activity
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0003016 respiratory system process
GO:0006068 ethanol catabolic process
GO:0006069 ethanol oxidation
GO:0007568 aging
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0032496 response to lipopolysaccharide
GO:0045777 positive regulation of blood pressure
GO:0046294 formaldehyde catabolic process
GO:0051409 response to nitrosative stress
GO:0051775 response to redox state
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028138
View Gene Order
ENSBTAG00000016007
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00830
Retinol metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa00350
Tyrosine metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.607419 Hs.714209 Hs.78989
RefSeq NM_000671
HUGO
OMIM
CCDS CCDS47111
HPRD 00064
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca