InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADH5

Summary

InnateDB Protein

IDBP-31069.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADH5

Protein Name

alcohol dehydrogenase 5 (class III), chi polypeptide

Synonyms

ADH-3; ADHX; FALDH; FDH; GSH-FDH; GSNOR;

Species

Homo sapiens

Ensembl Protein

ENSP00000296412

InnateDB Gene

IDBG-31067 (ADH5)

Protein Structure

UniProt Annotation

Function

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0005504	fatty acid binding
GO:0008270	zinc ion binding
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0018467	formaldehyde dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0003016	respiratory system process
GO:0006068	ethanol catabolic process
GO:0006069	ethanol oxidation
GO:0007568	aging
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0032496	response to lipopolysaccharide
GO:0045777	positive regulation of blood pressure
GO:0046294	formaldehyde catabolic process
GO:0051409	response to nitrosative stress
GO:0051775	response to redox state
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR014183 Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11766

PhosphoSite