Version 5.4
Homo sapiens Gene: FTO
Summary
InnateDB Gene IDBG-31147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FTO
Gene Name fat mass and obesity associated
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140718
Encoded Proteins
IDBP-31149
fat mass and obesity associated
IDBP-377069
fat mass and obesity associated
IDBP-480253
fat mass and obesity associated
IDBP-474283
fat mass and obesity associated
IDBP-484144
fat mass and obesity associated
IDBP-480187
fat mass and obesity associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:53703963-54121941
Strand Forward strand
Band q12.2
Transcripts
ENST00000268349 ENSP00000268349
ENST00000431610 ENSP00000415636
ENST00000471389 ENSP00000418823
ENST00000464071 ENSP00000418424
ENST00000460382 ENSP00000417422
ENST00000463855 ENSP00000417843
ENST00000472835
ENST00000570395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0035515 oxidative RNA demethylase activity
GO:0035516 oxidative DNA demethylase activity
GO:0043734 DNA-N1-methyladenine dioxygenase activity
Biological Process
GO:0001659 temperature homeostasis
GO:0006307 DNA dealkylation involved in DNA repair
GO:0010883 regulation of lipid storage
GO:0035552 oxidative single-stranded DNA demethylation
GO:0035553 oxidative single-stranded RNA demethylation
GO:0040014 regulation of multicellular organism growth
GO:0042245 RNA repair
GO:0044065 regulation of respiratory system process
GO:0060612 adipose tissue development
GO:0070350 regulation of white fat cell proliferation
GO:0070989 oxidative demethylation
GO:0080111 DNA demethylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055932
View Gene Order
ENSBTAG00000012501
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528833 Hs.636768
RefSeq NM_001080432
HUGO
OMIM
CCDS CCDS32448
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca