Version 5.4
Bos taurus Gene: FTO
Summary
InnateDB Gene IDBG-631892.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FTO
Gene Name alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012501
Encoded Proteins
IDBP-683464
protein fto
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140718:
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:22118201-22541532
Strand Forward strand
Band
Transcripts
ENSBTAT00000016588 ENSBTAP00000016588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0035515 oxidative RNA demethylase activity
GO:0035516 oxidative DNA demethylase activity
GO:0043734 DNA-N1-methyladenine dioxygenase activity
Biological Process
GO:0001659 temperature homeostasis
GO:0006307 DNA dealkylation involved in DNA repair
GO:0010883 regulation of lipid storage
GO:0035552 oxidative single-stranded DNA demethylation
GO:0035553 oxidative single-stranded RNA demethylation
GO:0040014 regulation of multicellular organism growth
GO:0042245 RNA repair
GO:0044065 regulation of respiratory system process
GO:0060612 adipose tissue development
GO:0070350 regulation of white fat cell proliferation
GO:0070989 oxidative demethylation
GO:0080111 DNA demethylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000140718
View Gene Order
ENSMUSG00000055932
View Gene Order
Cross-References
SwissProt
TrEMBL A5D798 G4V264 G4V268 G4V271 G4V273
UniProt Splice Variant
Entrez Gene 618622
UniGene Bt.108748 Bt.62264 Bt.65880
RefSeq NM_001098142 XM_005218739
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140478 DAAA02046444 DAAA02046445 DAAA02046446 DAAA02046447 DAAA02046448 DAAA02046449 DAAA02046450 DAAA02046451 DAAA02046452 DAAA02046453 DAAA02046454 DAAA02046455 DAAA02046456 DAAA02046457 GQ372973 GQ372974 GQ372977 GQ372978 GQ372980 GQ372981 GQ372982 HM777021 HM777022
GenPept AAI40479 ADJ51668 ADJ51669 ADJ51672 ADJ51673 ADJ51675 ADJ51676 ADJ51677 ADT80779 ADT80780
RNA Seq Atlas 618622

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca